{"id":24811,"date":"2026-07-08T11:15:09","date_gmt":"2026-07-08T09:15:09","guid":{"rendered":"https:\/\/www.biolife-publisher.it\/iji\/?p=24811"},"modified":"2026-07-20T12:52:51","modified_gmt":"2026-07-20T10:52:51","slug":"p53-is-an-important-component-of-the-antiviral-response","status":"publish","type":"post","link":"https:\/\/www.biolife-publisher.it\/iji\/p53-is-an-important-component-of-the-antiviral-response\/","title":{"rendered":"p53 IS AN IMPORTANT COMPONENT OF THE ANTIVIRAL RESPONSE"},"content":{"rendered":"

Di Gioacchino, Speranza L, Sanese G, Xhepa K. p53 is an integral component of the antiviral response.\u00a0 International Journal of Infection.\u00a0<\/em>2026;10(2):37-40.<\/p>\n

\n

M. Di Gioacchino1*<\/sup>, L. Speranza1<\/sup>, G. Sanese2<\/sup> and K. Xhepa2<\/sup><\/p>\n

1 <\/sup>Department of Medicine and Ageing Sciences, University \u201cG. D\u2019Annunzio\u201d, Chieti, Italy;
\n2 <\/sup>Neurosciences Imaging and Clinical Sciences Department, University \u201cG. D\u2019Annunzio\u201d, Chieti, Italy.<\/p>\n

*Correspondence to<\/em>:
\nMario Di Gioacchino,
\nDepartment of Medicine and Ageing Sciences,
\nUniversity \u201cG. D\u2019Annunzio\u201d,
\nChieti, Italy.
\ne-mail: dgioacchino@me.com<\/p>\n\n\n\n
Received: 11 May, 2026
\nAccepted: 01 July, 2026
\n\"adobe-pdf-download-icon\"<\/a><\/td>\n		ISSN 3103-6678 [online]
\nCopyright 2026 \u00a9 by Biolife Publisher
\nThis publication and\/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: all authors report no conflicts of interest relevant to this article.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

ABSTRACT<\/strong><\/p>\n

The p53 protein, encoded by the TP53 gene, is an important tumor suppressor known as the “guardian of the genome” because it controls DNA integrity, arrests the cell cycle and promotes DNA repair or apoptosis in case of irreparable damage. In addition to its antitumor function, p53 plays a crucial role in the antiviral response, inhibiting viral replication, promoting cellular arrest and enhancing immune responses mediated by interferons and innate immunity. Mutations in the TP53 gene impair these protective functions and are present in approximately 50% of human tumors, including those associated with viral infections. During viral infections, p53 plays an important antiviral role by inducing apoptosis of infected cells through the activation of pro-apoptotic genes such as BAX, PUMA, and NOXA, and by blocking the cell cycle via p21, thus limiting viral replication. Furthermore, p53 enhances the immune response by collaborating with interferons and promoting the production of innate immune cytokines. Because it represents an obstacle to viral replication, many viruses have developed mechanisms to inactivate it, such as human papillomavirus (HPV) with the E6 protein, adenovirus with E1B-55K, and SV40 with the large T antigen. p53 is a key antiviral and tumor-suppressor protein that regulates cell-cycle arrest, DNA repair, apoptosis, and immune responses during viral infections. In chronic hepatitis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), viral proteins interfere with p53 activity to promote oxidative stress, impaired apoptosis, genomic instability, TP53 mutations such as R249S, and the development of hepatocellular carcinoma. Similarly, SARS-CoV-2 can induce p53 degradation to enhance viral replication and immune dysregulation, although p53 also contributes to antiviral defence by limiting viral spread, cooperating with interferons, and eliminating infected cells through apoptosis.<\/p>\n

KEYWORDS:<\/strong> p53, gene, tumor suppressor, antiviral response, virus <\/em><\/p>\n

\u00a0<\/strong><\/p>\n

INTRODUCTION<\/strong><\/p>\n

 <\/p>\n

p53 is an important protein encoded by the TP53<\/em> gene and known as the “guardian of the genome” because it regulates the cell cycle, DNA repair, and apoptosis. p53 plays a role in maintaining stability by preventing mutations (1,2). The main function of p53 is to monitor DNA integrity, block the proliferation of damaged cells, and prevent tumor development (3).<\/p>\n

In viral infections, p53 is a key component of the host’s antiviral response (4). p53 inhibits viral infections, participates in cell arrest, enhances the immune response exerted by interferon alpha and beta, and mediates innate immunity. In addition, p53 blocks the proliferation of damaged cells and prevents the onset of tumors (5). p53 levels are very low in the cell, but it is activated following cellular damage through a process of phosphorylation (6).<\/p>\n

p53 is capable of halting cell replication in the G1 phase of the cell cycle by inducing DNA repair (7). Repair occurs by activating the expression of specific genes responsible for correcting genetic errors (8). Furthermore, if the cellular damage is severe and irreparable, p53 induces apoptosis, preventing the damaged cell from multiplying (9).\u00a0 p53 is a ubiquitous protein expressed in all cells, and the TP53 gene is one of the most important tumor suppressor genes in the human body (10). Mutations in this gene lead to dysfunction of the p53 protein, which can cause tumors (11).\u00a0 Mutations in this gene are very common and are present in approximately 50% of all human tumors, including those induced by viruses (12).<\/p>\n

 <\/p>\n

DISCUSSION<\/strong><\/p>\n

 <\/p>\n

In viral infections, p53 induces apoptosis in infected cells (13). It can activate pro-apoptotic genes such as BAX, PUMA, and NOXA, inducing cell death before the virus completes its replication cycle (14). In a metabolically active cell, p53 can block the cell cycle via p21, thus inhibiting viral replication (15,16).\u00a0 Interferons are viral inhibitors and interact with the p53 pathway, enhancing their biological activity and promoting the expression of various stimulated genes (17). Additionally, p53 can mediate the production of cytokines in the innate immune system (17,18). However, viruses counteract p53, which opposes viral replication, and have developed resistance mechanisms (19).<\/p>\n

For example, the human papillomavirus (HPV) possesses an E6 protein capable of degrading p53 via the ubiquitin-proteasome system (20). In adenovirus, the E1B-55K protein binds and inactivates p53, while in SV40, the large T antigen sequesters p53, preventing it from exerting its biological effect (21). p53 plays an important role in virally transmitted hepatitis, where chronic infections promote the development of pathological effects such as tumors, inflammation, and immune dysregulation (22). The interaction between p53 and Hepatitis B virus (HBV) and Hepatitis C virus (HCV) is one of the most important mechanisms through which these chronic infections promote the development of hepatocellular carcinoma (23).<\/p>\n

During infection, some viruses, such as HBV, can integrate their DNA into hepatocytes and alter p53 activity (24). In this context, the crucial viral protein is the HBV X protein (HBx), which binds to p53, inhibiting transcriptional activity and sequestering p53 in the cytoplasm, preventing it from reaching the nucleus (25). HBx also inhibits genes involved in apoptosis and DNA repair, an effect that allows infected cells to live longer and increases the number of mutations (14). Furthermore, the integration of viral DNA into the cellular genome alters the cellular genetic makeup and the action of p53 (26).<\/p>\n

In infections with RNA viruses, such as HCV, there is no integration of the genome between the virus and the host cell, but chronic infection induces oxidative stress and inflammation (27). In this case, several proteins interact with p53, such as the “core” proteins NS3 and NS5A (28). By acting on p53, the “core” protein modulates transcriptional activity, reduces the efficiency of apoptosis, and alters the intracellular localization of p53 (29). The NS3 and NS5A proteins interfere with the signals that activate p53, alter the DNA damage response, and promote the survival of infected cells (28).<\/p>\n

In HCV, there is continuous production of reactive oxygen species (ROS), activating repair mechanisms and oxidative DNA damage. p53 eliminates damaged cells, but viral interference reduces its effectiveness (30). Moreover, in HBV- and HCV-associated liver cancer, gene mutations of TP53 encoding p53 can occur, and the mutation at codon 249 (R249S) of the TP53 gene is the best known (31).<\/p>\n

In SARS-CoV-2 infection, p53 can also be altered by viral proteins, causing its degradation (32).\u00a0 This effect can promote viral replication and a dysregulated immune response. On the other hand, an excessive p53 response can cause apoptosis and tissue damage (33). Therefore, p53 can contribute to limiting viral shedding, eliminating infected cells, and preventing tissue damage. It blocks the proliferation of infected cells, acts in cooperation with interferons, and induces apoptosis (34).<\/p>\n

 <\/p>\n

CONCLUSIONS<\/strong><\/p>\n

 <\/p>\n

p53 is a key antiviral protein that cooperates with interferons alpha and beta, blocks the proliferation of infected cells, and induces apoptosis. However, many viruses have developed specific strategies to neutralize p53 to defend themselves from its effects. In viral infections, the effect of p53 on the pathogenic virus is considered an important mechanism in viral disease and tumor development.<\/p>\n

 <\/p>\n

Conflict of interest <\/em><\/p>\n

The authors declare that they have no conflict of interest.<\/p>\n

 <\/p>\n

REFERENCES<\/strong><\/p>\n

    \n
  1. Levine AJ. p53, the Cellular Gatekeeper for Growth and Division. Cell<\/em>. 1997;88(3):323-331. doi:10.1016\/s0092-8674(00)81871-1<\/li>\n
  2. Olivier M, Hollstein M, Hainaut P. TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use. Cold Spring Harbor Perspectives in Biology<\/em>. 2009;2(1):a001008-a001008. doi:10.1101\/cshperspect.a001008<\/li>\n
  3. Fei P, El-Deiry WS. P53 and radiation responses. Oncogene<\/em>. 2003;22(37):5774-5783. doi:10.1038\/sj.onc.1206677<\/li>\n
  4. Xia W, Jiang P. p53 promotes antiviral innate immunity by driving hexosamine metabolism. Cell Reports<\/em>. 2024;43(2):113724. doi:10.1016\/j.celrep.2024.113724<\/li>\n
  5. Hart M, Adams SD, Draviam VM. Multinucleation associated DNA damage blocks proliferation in p53-compromised cells. Communications Biology<\/em>. 2021;4(1):1-11. doi:10.1038\/s42003-021-01979-5<\/li>\n
  6. Sharpee TO, Destexhe A, Kawato M, et al. 25th Annual Computational Neuroscience Meeting: CNS-2016. BMC Neuroscience<\/em>. 2016;17(S1). doi:10.1186\/s12868-016-0283-6<\/li>\n
  7. Giono LE, Manfredi JJ. The p53 tumor suppressor participates in multiple cell cycle checkpoints. Journal of Cellular Physiology<\/em>. 2006;209(1):13-20. doi:10.1002\/jcp.20689<\/li>\n
  8. Kondo S. Apoptotic repair of genotoxic tissue damage and the role of p53 gene. Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis<\/em>. 1998;402(1-2):311-319. doi:10.1016\/s0027-5107(97)00311-4<\/li>\n
  9. Marcinkute M, Afshinjavid S, Fatokun AA, Javid FA. Fluoxetine selectively induces p53-independent apoptosis in human colorectal cancer cells. European Journal of Pharmacology<\/em>. 2019;857:172441. doi:10.1016\/j.ejphar.2019.172441<\/li>\n
  10. Kato S, Han SY, Liu W, et al. Understanding the function\u2013structure and function\u2013mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proceedings of the National Academy of Sciences<\/em>. 2003;100(14):8424-8429. doi:10.1073\/pnas.1431692100<\/li>\n
  11. Levine AJ. p53: 800 million years of evolution and 40 years of discovery. Nature Reviews Cancer<\/em>. 2020;20(8):471-480. doi:10.1038\/s41568-020-0262-1<\/li>\n
  12. Wu JK, Ye Z, Darras BT. Frequency of p53 Tumor Suppressor Gene Mutations in Human Primary Brain Tumors. Neurosurgery<\/em>. 1993;33(5):824-831. doi:10.1227\/00006123-199311000-00006<\/li>\n
  13. Moody CA, Laimins LA. Human papillomavirus oncoproteins: pathways to transformation. Nature Reviews Cancer<\/em>. 2010;10(8):550-560. doi:10.1038\/nrc2886<\/li>\n
  14. Hao Q, Chen J, Lu H, Zhou X. The ARTS of p53-dependent mitochondrial apoptosis. Journal of Molecular Cell Biology<\/em>. 2022;14(10):mjac074. doi:10.1093\/jmcb\/mjac074<\/li>\n
  15. Zhang M, Bi X, Liu S, Liu Y, Wang Q. The novel polyfluoroalkyl benzenesulfonate OBS exposure induces cell cycle arrest and senescence of rat pituitary cell GH3 via the p53\/p21\/RB pathway. Toxicology<\/em>. 2023;490:153511. doi:10.1016\/j.tox.2023.153511<\/li>\n
  16. Brady HJ, Gil-G\u00f3mez G. Bax. The pro-apoptotic Bcl-2 family member, Bax. The International Journal of Biochemistry & Cell Biology<\/em>. 1998;30(6):647-650. doi:10.1016\/s1357-2725(98)00006-5<\/li>\n
  17. Ghosh M, Saha S, Li J, Montrose DC, Martinez LA. p53 engages the cGAS\/STING cytosolic DNA sensing pathway for tumor suppression. Molecular Cell<\/em>. 2023;83(2):266-280.e6. doi:10.1016\/j.molcel.2022.12.023<\/li>\n
  18. Lim YJ, Lee J, Choi JA, et al. M1 macrophage dependent-p53 regulates the intracellular survival of mycobacteria. Apoptosis<\/em>. 2019;25(1-2):42-55. doi:10.1007\/s10495-019-01578-0<\/li>\n
  19. Yan MH, Wang LL, Hao JH, et al. Orf Virus VIR<\/em> Antagonizes p53-Mediated Antiviral Effects to Facilitate Viral Replication. Viral Immunology<\/em>. 2020;33(6):468-476. doi:10.1089\/vim.2019.0189<\/li>\n
  20. Vande Pol SB, Klingelhutz AJ. Papillomavirus E6 oncoproteins. Virology<\/em>. 2013;445(1-2):115-137. doi:10.1016\/j.virol.2013.04.026<\/li>\n
  21. Chalabi Hagkarim N, Ip WH, Bertzbach LD, et al. Identification of Adenovirus E1B-55K Interaction Partners through a Common Binding Motif. Viruses<\/em>. 2023;15(12):2356. doi:10.3390\/v15122356<\/li>\n
  22. Levrero M, Zucman-Rossi J. Mechanisms of HBV-induced hepatocellular carcinoma. Journal of Hepatology<\/em>. 2016;64(1):S84-S101. doi:10.1016\/j.jhep.2016.02.021<\/li>\n
  23. Jin Y. Hepatitis B and C virus infection and p53 mutations in human hepatocellular carcinoma in Harbin, Heilongjian Province, China. Hepatology Research<\/em>. 2002;24(4):379-384. doi:10.1016\/s1386-6346(02)00135-3<\/li>\n
  24. Cougot D, Neuveut C, Buendia MA. HBV induced carcinogenesis. J Clin Virol<\/em>. 2005;34 Suppl 1:S75-S78. doi:10.1016\/s1386-6532(05)80014-9<\/li>\n
  25. Kim S, Park J, Han J, Jang KL. Hepatitis B Virus X Protein Induces Reactive Oxygen Species Generation via Activation of p53 in Human Hepatoma Cells. Biomolecules<\/em>. 2024;14(10):1201. doi:10.3390\/biom14101201<\/li>\n
  26. Boutet M, Nishitani K, Couturier N, et al. Mutations in MLL3 promote breast cancer progression via HIF1\u03b1-dependent intratumoral recruitment and differentiation of regulatory T cells. Immunity<\/em>. 2025;58(8):2035-2053.e9. doi:10.1016\/j.immuni.2025.07.008<\/li>\n
  27. Loguercio C, Cuomo A, Tuccillo C, et al. Liver p53 expression in patients with HCV\u2010related chronic hepatitis. Journal of Viral Hepatitis<\/em>. 2003;10(4):266-270. doi:10.1046\/j.1365-2893.2003.00432.x<\/li>\n
  28. Siavoshian S, Abraham JD, Kieny MP, Schuster C. HCV core, NS3, NS5A and NS5B proteins modulate cell proliferation independently from p53 expression in hepatocarcinoma cell lines. Archives of Virology<\/em>. 2004;149(2):323-336. doi:10.1007\/s00705-003-0205-7<\/li>\n
  29. Braithwaite J. Relational republican regulation. Regulation & Governance<\/em>. 2012;7(1):124-144. doi:10.1111\/rego.12004<\/li>\n
  30. Seo YL, Heo S, Jang KL. Hepatitis C virus core protein overcomes H2O2-induced apoptosis by downregulating p14 expression via DNA methylation. Journal of General Virology<\/em>. 2015;96(4):822-832. doi:10.1099\/vir.0.000032<\/li>\n
  31. Hussain SP, Schwank J, Staib F, Wang XW, Harris CC. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene<\/em>. 2007;26(15):2166-2176. doi:10.1038\/sj.onc.1210279<\/li>\n
  32. Milani D, Caruso L, Zauli E, et al. p53\/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics). Frontiers in Pharmacology<\/em>. 2022;13. doi:10.3389\/fphar.2022.871583<\/li>\n
  33. Boon NJ, Oliveira RA, Pierr\u00e9-Ren\u00e9 K\u00f6rner, et al. DNA damage induces p53-independent apoptosis through ribosome stalling. Science<\/em>. 2024;384(6697):785-792. doi:10.1126\/science.adh7950<\/li>\n
  34. Major J, Crotta S, Llorian M, et al. Type I and III interferons disrupt lung epithelial repair during recovery from viral infection. Science<\/em>. 2020;369(6504):712-717. doi:10.1126\/science.abc2061<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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