Eur J Musculoskel Dis 2025 Sep-Dec;14(3): 136-140
CASE REPORT
HYALURONIC ACID RELIEVES PAIN IN A SORE KNEE BUT NOT IN ANTERIOR TALOFIBULAR LIGAMENT INJURY: CASE REPORT
F. Pandolfi1*, M.J. Conti2, M. Di Emidio3, A. Coppola4, F. Mastrangelo5 A. Younes6, G. Marinelli7, A.M. Inchingolo7, A.D. Inchingolo7 and G. Dipalma7
1 Immunology and Allergy, Internal Medicine Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy;
2 S. Andrea University “La Sapienza”, Rome, Italy;
3 University of L’Aquila, L’Aquila, Italy;
4 Private Practice, Studio Armando Coppola, Naples, Italy;
5 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy;
6 Medical Center “Mai più Dolore”, Pescara, Italy;
7 Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Bari, Italy.
*Correspondence to:
Prof. Franco Pandolfi,
Immunology and Allergy,
Internal Medicine Department,
Fondazione Policlinico Universitario A. Gemelli IRCCS,
Università Cattolica del Sacro Cuore,
Rome, Italy.
e-mail: pandolfi@rm.unicatt.it
| Received: 29 August, 2025 Accepted: 29 October, 2025
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ISSN 2975-044X (online) ISSN 2038-4106 (print) Copyright © by BIOLIFE 2025 This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: All authors report no conflicts of interest relevant to this article. |
ABSTRACT
Hyaluronic acid (HA) is effective in reducing knee pain in several inflammatory diseases (particularly in osteoarthritis). In this case report, we show that a single dose of 30 mg/2 ml HA injection eliminated pain in the knee but not in the painful anterior talofibular ligament. In the knee, the pain was eliminated after about 20 minutes, while in the torn ligament, the pain persisted. These results are probably due to the different nature of the tissue, and show that HA is more appropriate for synovial pain than tendon pain.
KEYWORDS: Hyaluronic acid, injection, inflammation, knee pain, anterior talofibular ligament
